Vemurafenib US FDA Label

  • Compound: N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide
  • Description: Vemurafenib is a pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone formal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases. It has a role as an antineoplastic agent and a B-Raf inhibitor. It is a pyrrolopyridine, a sulfonamide, a member of monochlorobenzenes, a difluorobenzene and an aromatic ketone.

Identifiers (10)

  • Brand Name: Zelboraf (Source: DrugBank)
  • ClinPGx ID: PA165946873 (Source: ClinPGx)
  • DrugBank ID: DB08881 (Source: DrugBank)
  • Drug Central ID: 4185 (Source: PubChem)
  • MeSH Entry Term: D000077484 (Source: Wikidata)
  • KEGG Compound ID: D09996 (Source: PubChem)
  • International Nonproprietary Name: VEMURAFENIB [INN] (Source: PubChem)
  • KEGG Drug ID: D09996 (Source: PubChem)
  • USFDA Precision ID: UNII-207SMY3FQT (Source: PubChem)
  • United States Adopted Name: Vemurafenib [USAN] (Source: PubChem)

    • Sources: DrugBank (2) ClinPGx (1) PubChem (6) Wikidata (1)

    Information (3)

  • Clinical Indication: Vemurafenib is a novel, oral small molecule designed to treat melanoma and other cancers harboring the oncogenic V600E BRAF mutation (rs113488022) [Article:22646766]. It can also inhibit non-mutant BRAF and RAF1 and showed activity against ACK1 (also known as TNK2), KHS1 (MAP4K5) and SRMS in vitro [Article:22646766]. (Source: ClinPGx)
  • Description: Vemurafenib is a selective inhibitor of BRAF kinase that is used in the therapy of patients with metastatic and advanced malignant melanoma. Vemurafenib therapy is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe cases of clinically apparent acute liver injury. (Source: PubChem)
  • Description: A medication used to treat patients with a rare condition called Erdheim-Chester Disease and a type of skin cancer called melanoma. (Source: DrugBank)

    • Sources: ClinPGx (1) PubChem (1) DrugBank (1)